Solid support for large-scale oligonucleotide production plays a crucial role in determining both the quality and cost of drug molecules. Sunresin has developed specialized solid supports that underwent extensive evaluation through SPOS testing at Ionis Pharmaceuticals. Following promising outcomes, polymerization processes were scaled to 1,000 L volumes. In total, six replicate batches were produced in a 1,000 L reactor, yielding 20-30 kg of resin, which were tested against other commercial option.

The resultant product, Seplife® Unylinker-OH, features a high yield and is competitively priced for bulk orders of 20 kg or more which positions it as a highly cost-effective solution in the market for oligonucleotide synthesis.