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Tackling the challenge of enhancing cytotoxic payload potency while reducing off-target toxicity in ADCs

18 Jun 2025
Cytotoxic Payload
  • How can we improve the potency of cytotoxic payloads without increasing off-target toxicity in ADCs?
  • What strategies can be implemented to ensure selective payload delivery to tumor cells while minimizing collateral damage to healthy tissues?
  • How do different cytotoxic payload classes (e.g., auristatins, maytansinoids) compare in terms of potency and selectivity?
  • What role do payload-linker interactions play in controlling the release of the cytotoxic agent, specifically at the tumor site?
  • How can we better predict and mitigate systemic toxicity from potent cytotoxic payloads in clinical ADC development?