Balancing linker stability to ensure controlled payload release without compromising ADC efficacy
18 Jun 2025
Linker Design
- How can we design linkers that remain stable in circulation while ensuring efficient payload release at the tumor site?
- What are the key chemical and biological factors that influence linker stability in ADCs?
- How do different linker strategies impact the pharmacokinetics, efficacy, and safety of ADCs?
- What advancements in linker technology are addressing premature payload release and systemic toxicity?
- How can we leverage predictive models and analytical techniques to optimize linker stability during ADC development?